Speaking during a meeting with top Judiciary officials, the Leader said the American officials, fearing Iran's might, are now attempting to bring Iran to the negotiating table so they could wreak havoc on it.
The Leader's remarks came two days after the USA imposed new sanctions targeting Ayatollah Khamenei's office and senior commanders of the Islamic Revolution Guards Corps (IRGC).
The Trump administration has since said it is open to talks with Tehran, an offer flatly rejected by Rouhani after the United States said it would also sanction his top diplomat. That will hurt Tehran far more than a limited military strike would have.
There is now no one left within the Trump administration ready to block the anti-Iranian hard-liners and disputes in the Middle East are intensifying.
Iran and world powers including the United States who signed the nuclear pact needed to find a way back into talks to defuse tensions, French President Emmanuel Macron said on Wednesday.
He said he also wasn't "talking boots on the ground".
Wherever it was, Trump backed off a plan to attack Iran because it would have caused 150 casualties, which Trump thought a "disproportionate" punishment for downing a pilotless drone.
Iranian President Hassan Rouhani on 8 May responded to U.S. pressure by announcing that Iran would partially suspend its compliance with the JCPOA.
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However, according to the USA president, the Iranian leadership needs to change first. Iran rejected these demands, which include terminating ballistic missile development, accepting unrestricted inspections of nuclear-related and military facilities, and ceasing support for "terrorist organisations". His message was clear: Iran got one free pass; it may not get another. "Iran's very ignorant and insulting statement, put out today, only shows that they do not understand reality".
Tensions between the USA and Iran also include Trump walking away from a previous nuclear deal with Iran set up by former President Barack Obama. The US has also accused the IRGC of carrying out attacks on tankers in the Gulf of Oman.
Help us grow and continue telling Israel's story to the world. Iran is more inclined to resort to escalatory measures, particularly as it expects Trump to feel the pressure to resolve the Iran issue without getting involved in a war as he begins to campaign for re-election. If the other JCPOA signatories failed to fulfil their obligations with respect to financial transactions and crude oil trading within 60 days, Iran would begin phasing out its adherence to other obligations.
"You're not going to need an exit strategy", President Trump said. A deal with Iran, he said, must "eliminate Iran's nuclear weapons program, its pursuit of ballistic missile delivery systems, its support for global terrorism and other malign behavior worldwide".
That appears to have had a knock-on effect on Hezbollah, the Lebanese political party and militia group closely linked to Iran. Officials, undoubtedly guided by the supreme leader's office, cited "humiliating conditions".
Tehran accuses Washington of waging economic warfare through its crippling sanctions regime, which on Monday saw Iran's supreme leader Ayatollah Ali Khamenei blacklisted. The CRS report from last month says Iran's 2018-2019 defense budget had in fact risen to $25 billion dollars, "up from about $23 billion in 2017". Also, Abe could try to persuade Trump not to provoke Iran, if he really desires a direct negotiation with Iran. The 2015 deal allows Iran to sell excess uranium overseas to keep its stockpile below the limit, but such sales have been blocked by USA sanctions.