He hit a wall.
Froome - a four-time victor of cycling's biggest event - was taken to hospital after crashing during a reconnaissance ride ahead of stage four of the Criterium du Dauphine.
Team manager Dave Brailsford told French TV that Froome had suffered a "very serious accident", believed to be a fractured pelvis, and would miss out on cycling's most prestigious event.
Britain's four-times Tour de France victor Chris Froome will not start next month's race after sustaining multiple fractures, including a broken right femur, following a heavy crash in the Criterium du Dauphine on Wednesday, Team Ineos said. "There are crashes and bad crashes and this was a bad crash".
Brailsford said Froome was riding in gusty winds and seemed to lose control of his front wheel when trying to clear his nose.
The four-time victor of the Tour de France crashed towards the end of the recon in Auvergne-Rhone-Alpes and his injuries include a fractured right femur, a fractured elbow and fractured ribs.
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"Even though we all recognise the risks involved in our sport, it's always traumatic when a rider crashes and sustains serious injuries".
Chris Froome has been forced to abandon the Critérium du Dauphiné after the Ineos rider crashed during a reconnoitre of Wednesday's fourth stage.
Seeking a fourth win in the key preparation race, Froome was eighth in the Dauphine standings, 24 seconds behind leader Dylan Teuns of Belgium. But in 2014 having started as the Tour's absolute favourite, Froome's dramatic crash-out following repeated falls in the rainsoaked first week left that year's Tour wide open.
The Tour de France starts July 6 in Brussels.
"We're going to do all we can to support Chris in his bid to win a fifth Tour, to cement his place in history and join the exclusive club of five-time winners".
It was immediately feared the 34-year-old had broken his leg and, after being taken to a local hospital, further injuries were confirmed as his hopes of a fifth Tour title this year were dashed.