The chaotic scene unfolded in north Seattle just after 4 p.m. Police said that a man approached a 56-year-old female driver in the street and shot her.
Seattle Police chief Carmen Best said her "heart goes out to those affected by today's tragedy". During the chase, a 70-year-old driver collided with the suspect's vehicle head-on and suffered fatal injuries, dying at the scene.
A bus driver hailed as a hero for steering his bus away from a gunman who opened fire in Seattle on him and his passengers says he was just doing his job but is "glad to be alive".
None of the 12 passengers onboard were injured, it said on Twitter.
(AP Photo/Gene Johnson) Seattle Fire Chief Harold Scoggins, left, and Deputy Police Chief Marc Garth Green give a media briefing following a shooting in Seattle on Wednesday, March 27, 2019.
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One of the victims was a bus driver on the Metro Route 75, according to Metro.
The suspect first shot a driver near Sand Point Way NE and Bartlett Avenue NE.
After the police's arrival, the accused carjacked the Prius and tried to flee the scene but collided with another vehicle, killing the other driver.
Having been shot in the chest, the bus driver is said to have put his vehicle into reverse and driven for a few blocks. before pressing an emergency button and alerting police to the scene at 4:05 pm. After a brief standoff with authorities, Seattle Police took the suspect into custody.
The Bureau of Alcohol, Tobacco and Firearms assisted Seattle police and the Seattle Fire Department in the investigation, the local division confirmed.
After firing upon the bus, the suspect stopped a red Prius on the road and shot the driver, a man in his 50s. Several bullet holes pierced the bus' windshield. Police have asked people to avoid the area.
"This is a tragedy for the Lake City community & all of Seattle". Metro has rerouted bus routes 64 and 65 off Northeast 125th Street.