The New York Police Department says that at 9:17 p.m. ET, officers received a 911 call reporting an assault in progress in front of Cali's house at 25 Hilltop Terrace.
Media, including the New York Post, reported that Cali was shot at least six or seven times and also run over by a blue pickup truck driven by the shooter, citing unidentified police sources.
'The man was on the ground face-up.
The Gambino operation is said to be one of the five historic Italian-US mafia families in NY. His head was by his SUV, and the truck was open'.
Cali, who was known throughout his life as "Franky Boy", is the nephew-in-law of Sicilian mobster John Gambino and had close ties to the Sicilian Mafia family led by Salvatore Inzerillo. Unlike the well-dressed Dapper Don of the late 80s and early 90s, Cali had kept a low profile.
The last crime family boss to be shot in New York City was Paul Castellano.
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Since Gotti's downfall, the Gambinos - and other mafia families - have lost much of the power they once had over politicians, judges and labor unions.
Authorities have claimed the 53-year-old Cali is the boss of the Gambino crime family, previously headed by the infamous John Gotti.
A native of Sicily, Cali has deep mob roots, and his wife is the niece of Gambino capo John Gambino.
He had just one criminal conviction: an extortion charge in 2008 for an attempted shake down of a trucker working at a proposed NASCAR race track in Staten Island.
The New York Daily News reported in 2008 that Cali was among 62 people arrested on federal racketeering charges and he later pleaded guilty to conspiring to extort money.
Rudolph W. Giuliani, who at the time was the United States Attorney for the Southern District of NY, condemned the killings and vowed to find those responsible. He was sentenced to 16 months in federal prison and was released in 2009.