The health officials say another man was shot dead by Israeli troops close to the fence overnight.
Two Palestinians were killed by Israeli forces near the perimeter fence with Israel on Saturday, hours before thousands gathered for a protest there to mark the first anniversary of weekly protests along the Gaza Strip border, according to Palestinian medical officials.
"The Palestinian resistance is ready for any scenario", Barhoum continued.
Two million Palestinians live in impoverished Gaza, crammed between Israel, Egypt and the Mediterranean. Many live just a few kilometres from their villages of origin.
On March 25, a rocket fired from the Gaza Strip hit a residential building in the community of Meshmeret, in central Israel north of Tel Aviv.
Thousands of Palestinians rallied at the Gaza-Israel border on Saturday to mark the first anniversary of a surge of protests, facing off against Israeli forces massed across the frontier. We marched on the fence of the Gaza concentration camp marking Land Day and the one-year anniversary of the March. Palestinians have also launched incendiary balloons and kites into Israel and breached the Israeli frontier fence.
Yet despite the staggering toll of death and injury, and calls for accountability, Al Mezan said that "the worldwide community remains divided and hesitant to take a firm stance on the serious and increasing departures from global law standards and principles".
Most participants in the Great March of Return demand a complete break with the Oslo process and its vision of a Bantustan alongside a Jewish state that practices racism against its own people.
This dream of breaking Israel's colonial borders has dominated the imaginations of many Palestinians.
Turkish lira weakens again after rocky pre-election week
The Turkish lira is now down 1.5 percent versus the American greenback and is trading at 5.6442 as of just after 2:00PM UK time. As of 1510 GMT, it had clawed back some of its losses to 5.57. "We should discipline the speculators in the market", he said.
As Great March of Return organiser Ahmed Abu Artema asked: "What if 200,000 demonstrators marched peacefully and broke through the fence east of Gaza and entered a few kilometres into the lands that are ours, holding the flags of Palestine and the keys to return, accompanied by global media, and then set up tents inside and established a city there?"
Despite the bleak reality of life in Gaza - which Israel's siege will, with global and local collusion, soon render uninhabitable - a new consciousness is emerging.
The Israeli government designates Hamas a terrorist group which it says has been seeking to use the protests as a cover to cross into its territory and carry out attacks. "Some of those violations may constitute war crimes or crimes against humanity".
Hamas has been mobilising its resources and urging Palestinians to come out in force to five locations along the Israeli security fence on Saturday. This is why we tend to believe that the Great March of Return has the potential to revive the concepts of national liberation and self-determination by addressing the new facts on the ground that Israel created.
The Gazan Health Ministry said Saturday that at least 316 Palestinians had been injured.
Adham Nidal Amara, 17, was directly injured in the face and killed as he took part in the rallies east of Gaza City, and Tamer Hisham Abu al-Khair, also 17, was fatally shot in the chest, east of Khan Younis. This unliveable life is what led Hasan Shalabi to the protests last month. The children were returned to Gaza through a border crossing.
A large number of the casualties have been unarmed Palestinians and medics with clearly marked clothing, which has "raised concerns" about Israel's use of excessive force.