Rafael Nadal and Roger Federer eased through as Novak Djokovic departed on a day of upsets at the Indian Wells Masters.
In match that resumed after rain stopped play just one game in on Monday night, Kohlschreiber said the warmer daytime conditions suited him better, and Djokovic agreed. "Second set, it was definitely better".
Krajinovic will be a big underdog when he faces Spain's world number two Rafa Nadal, who crushed Argentine Diego Schwartzman 6-3 6-1 on the showcase court to reach the last 16.
"He's also up and coming, so that's fun", Federer said of Hurkacz.
His nervousness against the 20-time Grand Slam champion was evident and despite the second set being a closer affair, it was the Swiss superstar who booked his place in a 13th Indian Wells quarter-final.
"Today, I played very well, and took my chances".
Federer, current world number four, disarmed his opponent from the beginning and took the first five games on Wednesday.
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Kecmanovic, ranked 130th in the world, had taken the first set against Yoshihito Nishioka 6-4 when the 74th-ranked Japanese retired because of injury.
Kecmanovic became the first lucky loser to reach the last eight at Indian Wells since the ATP's Masters 1000 series launched in 1990.
Kecmanovic is the last teen left in the men's draw, after the departure of 19-year-old Shapovalov.
The 22-year-old will next face Canadian teenager Denis Shapovalov, who continued his run of dominant serving without being broken on his way to an impressive 6-4 6-2 win over 10th seeded Croat Marin Cilic.
Thiem needed less than an hour to subdue the 89th-ranked Karlovic, surrendering just seven points on his own serve and punishing Karlovic's second serve.
"He's the best player to ever play the sport", Wawrinka said.
Djokovic's loss came on the same day that women's world number one Naomi Osaka saw her title defense hopes dashed, falling 6-3 6-1 to Belinda Bencic. We know each other well, so it's a positive victory for me, " Nadal said. I was able to mix up my game, cover my serve, be risky on the return.