"The 2020 presidential election is around the corner", said Lee. Make the moral choice between love and hate. Let's all mobilise, let's all be on the right side of history.
At the conclusion of his speech, Lee exclaimed, "Do the right thing!".
At the podium, Lee thanked family, including the grandmother whose social security checks gave him tuition for Morehouse College, along with the New York University program, where he is now a professor.
Lee ended his speech - which had Jordan Peele in tears - on a political note.
Huawei Mate X officially announced, looks impressive
Powering Huawei's new futuristic hardware is the firm's Kirin 980 processor, the same as is present inside the Mate 20 Pro . Hot on the heels of the reveal of Samsung's Galaxy Fold , Huawei announced its foldable display smartphone, the Mate X .
Before Spike Lee became an Oscar victor on Sunday night, he had a prediction that now seems eerily prescient.
Other big winners of the night includes Rami Malek who won his first Oscar y for his portrayal of late Queen frontman Freddie Mercury in musical Bohemian Rhapsody. They also won the British Academy Film and Television Arts award, also known as BAFTA, in the same category earlier this month.
John David Washington stars in BlacKkKlansman as real-life police officer Ron Stallworth, who helped infiltrate the Ku Klux Klan in 1970s Colorado.
The film was nominated for a total of six Oscars, including best picture, film editing and original score. Jackson, who presented the award on Sunday, was nominated in 1994 for his supporting role in Pulp Fiction.