The Pentagon Friday confirmed it had begun pulling out some equipment from Syria as part of the pull-out, but that some 2,000 US forces would remain in place until conditions on the ground allowed for them to leave.
According to the Syrian Observatory for Human Rights, the London-based group monitoring Syria's civil war, and the local Manbij Military Council, more than a dozen people were killed or wounded in the attack.
The attack comes as the USA prepares to withdraw troops from Syria - a decision Pence defended in his Wednesday morning remarks. He announced in December he would be pulling out about 2,000 American troops in Syria. Support our independent reporting and analysis today by considering a one-time or monthly donation.
White House spokeswoman Sarah Sanders said President Donald Trump has been briefed on the situation.
It was not the first time that forces of the US-led coalition were subjected to attacks in the area, although they have been rare.
Islamic State later put out a statement saying a Syrian fighter had detonated his explosive vest while targeting a foreign patrol in Manbij. We certainly have done a lot of damage to ISIS and kicked it out of its most prominent redoubts, but we have not defeated ISIS in Syria. "We are still gathering information and will share additional details at a later time". Coming days after Trump's decision to withdraw troops from Syria, it centered on the remaining challenges of going after ISIS fighters in pockets of Syria.
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In addition to the two troops, whose military service was not identified, one Defense Department civilian and one American contractor supporting defense operations were killed, officials with U.S. Central Command announced.
A recent USA report said there were still as many as 14,000 IS militants in Syria and even more in neighbouring Iraq - and that they were expected to shift to guerrilla tactics in an attempt to rebuild their network.
"Trump wants to implement these safe regions through cooperation with Turkey".
President Trump warned Erdogan that he would "devastate Turkey economically if they hit Kurds", in a tweet posted Sunday night. "We'll be coming out of Syria, like, very soon".
The attack comes just weeks after Trump announced he was pulling out all 2,000 United States troops from Syria because ISIS was defeated, though he later tweeted that the terror group was "largely defeated".
Another important development to watch is the upcoming meeting on Syria between Turkish President Recep Tayyip Erdogan and Russian President Vladimir Putin scheduled for January 23 in Moscow. And now I'm seeing it in Syria'.