The highly-anticipated match will be played on November 4, Sunday, and it will start at 7 pm India time.
With Kohli rested for the three matches, Rohit Sharma will lead the side against the reigning T20 champions.
For the clash at historic Eden Gardens, there will be no Chris Gayle - the most successful batsman ever in T20s - nor any Evin Lewis, who has already plundered two centuries in 17 matches. "There will be an official update", West Indies media manager told media at the news conference. In his absence, young Delhi batsman Rishabh Pant will don the gloves for India.
Earlier, the West Indies top order failed while its less-accomplished lower order sparkled with the bat to offer India a fighting score.
Karthik first revived India's chase with Manish Pandey (19) and then found an able ally in Pandya, whose clever and nerveless batting stood out.
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Besides leading India to their maiden and only T20 World Cup triumph in 2007, Dhoni is also the most capped player in the shortest format, featuring in 93 of India's 104 matches.
Krunal Pandya is the only all-rounder in team that has 3 pacers - Bhuvneshwar Kumar, Jasprit Bumrah and Khaleel Ahmed and two spinners in Kuldeep Yadav, and Yuzvendra Chahal. The contest will be competed at Eden Gardens, in Kolkata.
A weakened but still risky West Indies will clash with powerhouses India in the opening Twenty20 global here Sunday, hoping to spring a surprise and also halt their decline in what has become their most successful format.
Hetmyer, 21, is also in superb form scoring 259 runs in the ODI series including the counter-attacking 106 in Guwahati. Shahbaz Nadeem and Khaleel Ahmed have also been named for this series. The latter has only two wins to its credit while one match was abandoned. Hosts India have been dominating them since the start of the series in October. Rishabh Pant is confirmed to be a part of the playing XI.
Winning Super50 Cup Captain, Carlos Brathwaite will turn his attention to the Windies as he heads a 14-man squad for three T20Is against India, starting tomorrow, November 4.