The murder convictions led to Little being referred to the FBI's Violent Criminal Apprehension Program (ViCAP) - a scheme that works to analyse serial offenders of violent and sexual crimes, and share information with local law enforcement agencies to cross-reference unsolved crimes.
The FBI says Little remains in poor health and will likely stay in Texas prison until his death. "He remembers where he was, and what auto he was driving".
The FBI said the challenge in connecting the dots is partly due to the fact that Little moved around frequently and often preyed on vulnerable women, some of whom were believed to be involved in the sex trade or addicted to drugs.
"The biggest lesson in this case is the power of information sharing", Kevin Fitzsimmons, ViCAP's supervisory crime analyst, said in the report. "He draws pictures of numerous women he killed", adding that Little is a little less reliable when it comes to remembering dates of such killings, however.
Little, 78, was convicted in 2014 of killing three women in Los Angeles in the late 1980s and has recently been confessing to killing 90 other women across the southern and eastern U.S. He is serving three life sentences with no possibility for parole. "Thus far, the team has confirmed 34 killings with many more pending confirmation".
"In all three cases, the women had been beaten and then strangled, their bodies dumped in an alley, a dumpster, and a garage", said the Federal Bureau of Investigation.
Many more are pending confirmation while a number of Little's confessions remain uncorroborated.
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He also said that the parents were informed of the potential risks of the off-target edit. He did not name the journal and said his university was unaware of his study.
Investigators say their bodies were often left unidentified and their deaths un-investigated by authorities.
Ridgway, who is serving a life sentence, pleaded guilty to killing 49 women and girls, making him the most prolific serial killer in USA history in terms of confirmed kills, though he has said he likely killed more than 71.
Little allegedly provided details to a Texas Ranger that linked him to Odessa, Texas, at the time 38-year-old Denise Christie Brothers disappeared and died. They say he was able to draw pictures of many of his victims. "The FBI is also encouraging law enforcement to re-visit their cold cases and contact ViCAP if they have any information", an FBI spokeswoman said in an e-mail. "Jackson, Mississippi - one; Cincinnati, Ohio - one; Phoenix, Arizona - three; Las Vegas, Nevada - one", ViCAP Crime Analyst Christina Palazzolo said in the report.
From the time Little dropped out of high school and left his OH home in the late 1950s, he lived a nomadic life.
Little's method of killing did not always leave clear signs that the death was a homicide. The FBI said Little - as a one-time competitive boxer - usually punched his victims to stun or knock them before strangling them.
A large number are believed to have taken place in the 1970s and early 1980s before DNA technology was available to police. "These connections all started in our database of violent crime". He remains in the custody of Odessa, but has been housed in Wise County for some time to be closer to Holland, who has been conducting almost daily interviews to create the most accurate accounting possible of Little's crimes. That is the value of ViCAP.
The FBI has released an extensive list and map pertaining to the homicidal claims made by a convicted murderer who is now claiming to be America's most prolific active killer.