All of Paradise, a town of about 27,000 people 180 miles (290 kilometers) northeast of San Francisco, was ordered to evacuate, said Butte County Sheriff's spokeswoman Miranda Bowersox.
Evacuation orders are in place for Paradise, Magalia, Concow, Butte Creek Canyon and Butte Valley while hundreds of firefighters battle the blaze.
Fire officials were working on a plan to rescue patients from a hospital after officials tried to evacuate them but had to turn back because of gridlocked traffic.
"We're trying to get as many people out as quickly as possible and save as many lives as we can", he said.
Camp Fire in Butte County. Fire officials said some structures have been destroyed in addition to injuries. The Associated Press said the Ventura County Fire Department had ordered evacuation of some communities in the path of the flames - not far from the site of a deadly mass shooting at a bar in the city of Thousand Oaks.
The fire forced the evacuation of patients from Paradise's main hospital to hospitals in Oroville and Chico. It's very surreal. Things always work out, but the unknown is a little scary.
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"This is the type of situation where, if a fire starts, it can spread rapidly", May said. "We had to ride through flames to get here", he said from the side of a road west of Paradise.
Evacuated hospital patients are being taken to hospitals throughout the region. A California fire official says a fast-moving wildfire in Northern California has destroyed structures and injured civilians.
A wildfire in Northern California has grown to almost 8 square miles (20 square kilometers) as officials rush to evacuate residents. "God help us!" she said before breaking down crying.
The California Highway Patrol closed a nearby highway and urged motorists to avoid the area.
"We had to drive through flames to make it out safely", she said.
Yesterday, Cal Fire officials said that parts of Northern and Southern California was under a "red flag" warning for critical fire weather "due to gusty winds, dry fuels & low humidity".
Bernacett said she and her husband "knocked on doors, yelled and screamed" to alert as numerous residents of 53 mobile homes and recreational vehicles as possible to leave the area Thursday morning as authorities ordered the area evacuated.