They will also close two unnamed factories outside North America. In October, nearly 65 percent of new vehicles sold in the U.S. were trucks or SUVs.
Tesla (TSLA), the leading electric vehicle maker, already hit the 200,000 milestone earlier this year.
GM is shedding cars largely because it doesn't make money on them, Citi analyst Itay Michaeli wrote in a note to investors.
The White House is threatening to curtail federal subsidies for electric cars in response to General Motors' decision to shut down auto production at plants in OH and MI.
GM isn't the first to abandon much of its vehicle market.
The planned job reductions, which triggered political pushback in the Midwest U.S. and Canada, come on the heels of surprisingly strong third-quarter earnings.
General Motors is closing a Canadian plant at the cost of about 2,500 jobs, but that is apparently just a piece of a much broader, company-wide restructuring that will be announced as early as Monday.
Those cuts are in addition to $6.5 billion that the company has announced by the end of this year.
GM Chief Executive Mary Barra spoke to Trump over the weekend to discuss the cuts and was at the White House on Monday to meet with economic adviser Larry Kudlow. She also suggested that tariffs Trump imposed on imported aluminum and steel have hurt the company.
"GM workers have been part of the heart and soul of Oshawa for generations - and we'll do everything we can to help the families affected by this news get back on their feet", he said.
MS senator banking on boost from Trump rallies
The above-linked article (read it in full) notes that her official bio "conspicuously" omits mention of her high school years. Trump heads to MS on Monday to campaign for Hyde-Smith - his second trip to the state on the senator's behalf since October.
General Motors blamed the decision on declining sales of small and mid-sized cars and said it would focus on making more large sport-utility vehicles. However, this subsidy goes away once an auto maker reaches 200,000 electric cars sold.
GM has offered buyouts to 18,000 retirement-eligible workers with a dozen or more years of service.
Even as GM is moving to lay off salaried staff, the company is hiring. It's not clear precisely what, or when, action may be taken.
Too many of GM's factories are operating on a single shift to build models that have fallen out of favor, leading its plants to run about 1 million vehicles short of their full capacity, said Kristin Dziczek, vice president of industry, labor and economics for the Center for Automotive Research in Ann Arbor, Michigan.
"They say the Chevy Cruze is not selling well".
The United Automobile Workers (UAW) union vowed to "confront this decision by GM through every legal, contractual and collective bargaining avenue open to our membership". The automaker says the decision to reduce American production has to do with reduced demand for cars like the Chevrolet Cruze, which is built at the OH plant, and an overall strategic shift towards more popular crossover and SUV models. LaCrosse and Volt production will end March 1, while CT6 and Impala production would stop June 1.
Alongside two plants in MI, one in Maryland, and one in Ontario, Canada, GM said one of the plants targeted to be closed-or, um, "unallocated" in the bad PR-jargon used by GM in the announcement-is just outside of Youngstown, Ohio.
GM will stop producing cars and transmissions at the plants through 2019.
Also, GM is getting close to the point at which the EV tax credit starts to phase out.