The victory keeps Barca joint top of Champions League Group B with Inter Milan, who they play next, and saw them snap a run of four Champions League away games without a win. "In the second half, we were very competitive and did everything we could to try to come back".
"You dream of playing in games like this and especially against players like Messi", said Keiran Trippier.
Only when Messi struck his second in stoppage-time, his fifth of this season's tournament after a hat-trick against PSV, could coach Ernesto Valverde breathe a little easier.
"We have to be happy because things went our way this time", Messi added. We were handicapped against Barcelona after conceding after one minute. "In the second half, he had more space and that is hard to stop", added Pochettino.
Tottenham refused to surrender as Harry Kane pulled a goal back but Messi took centre stage in the second half, the five-time Ballon d'Or victor finding the bottom corner of the net - having hit the post twice - before the superstar swept home a second during the closing stages after Erik Lamela struck for Spurs.
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Manchin declined, saying in a statement he will continue to listen to residents on the issue but will base his decision on facts. And he says those accusations have been seized on by "the far left that has been so eager to stop this nomination".
Messi then put Barca 3-1 in front at the end of another flowing move, only for Erik Lamela to pull another back for Spurs with a deflected shot from the edge of the penalty area.
Losing Eriksen, Alli, Mousa Dembele and Jan Vertonghen through injury ahead of such a big night was a cruel blow for Pochettino.
The double strike against Spurs took his all-time Champions League goal tally to 108 - just 13 behind Cristiano Ronaldo - and he has now scored a remarkable 22 goals in 29 appearances against English clubs. Spurs bounced back by winning their last two Premier League matches.
Suarez also scored just once in this competition last season, but although the statistics are pretty damning, it is too soon to write the former Liverpool man off as a has-been on the highest stage.
A gallant Tottenham side, missing the likes of Dele Alli, Christian Eriksen and Jan Vertonghen, nearly levelled when Lucas Moura's shot deflected wide but Messi ended their resistance after again being picked out by Alba.